Cholecystokinin-induced Inhibition of Presympathetic Vasomotor Neurons: Dependence on Sub-diaphragmatic Vagal Afferents and Central Nmda Receptors in the Rat
نویسندگان
چکیده
Short running title: RVLM presympathetic neurons and cholecystokinin Address for Correspondence: Dr Anthony J.M. Verberne Clinical Pharmacology and Therapeutics Unit Department of Medicine Austin Health Heidelberg Victoria 3084 AUSTRALIA Tel: 61 (0)3 9496 5978 Fax: 61 (0)3 9459 3510 Email: [email protected] Articles in PresS. Am J Physiol Regul Integr Comp Physiol (May 20, 2004). 10.1152/ajpregu.00258.2004
منابع مشابه
CCK-induced inhibition of presympathetic vasomotor neurons: dependence on subdiaphragmatic vagal afferents and central NMDA receptors in the rat.
Systemic administration of cholecystokinin (CCK) inhibits a subpopulation of rostral ventrolateral medulla (RVLM) presympathetic vasomotor neurons. This study was designed to determine whether this effect involved subdiaphragmatic vagal afferents and/or central N-methyl-d-aspartic acid (NMDA) receptors. Recordings were made from CCK-sensitive RVLM presympathetic vasomotor neurons in halothane-a...
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Ingestion of a meal results in gastrointestinal (GI) hyperemia and is associated with systemic and paracrine release of a number of peptide hormones, including cholecystokinin (CCK) and 5-hydroxytryptamine (5-HT). Systemic administration of CCK octapeptide inhibits a subset of presympathetic neurons of the rostroventrolateral medulla (RVLM) that may be responsible for driving the sympathetic va...
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Cholecystokinin (CCK) is released after a meal to promote digestion and satiety. Circulating CCK inhibits splanchnic sympathetic nerve activity (sSNA), which may contribute to postprandial increases in mesenteric blood flow. The CCK-induced sympathoinhibition occurs by activation of vagal afferent nerves and inhibition of a subset of presympathetic rostral ventrolateral medullary (RVLM) neurons...
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